报告题目： Nanoparticles  for Therapeutic Delivery of Oligonucleotides

报告时间：  4月24日星期二下午14:30

报告地点：  科大西区力二楼215教室

报告人：  Dr. Robert Lee，  Professor of Pharmaceutics and Pharmaceutical Chemistry， The Ohio State  University 

报告摘要：

Oligonucleotides  including antisense oligos, siRNAs, miRNA mimics, and antimiRs can specifically  regulate gene expression and are an emerging therapeutic modality. Drug  approvals in this area have accelerated in recent years.  A major barrier to  clinical development of oligonucleotide therapeutics is the lack of safe and  efficacious delivery systems.  There are a multitude of biological barriers that  must be overcome for oligo drugs, such as nuclease degradation and low membrane  permeability. Nanoparticles are promising vehicles for delivery of  oligonucleotides. However, their clinical development has a mixed record, due to  unexpected off target effects and induction of cytokine release syndrome.  Despite setbacks, nanoparticles hold great promise for future success due to its  versatility and multifunctional capabilities. 

个人简介： 

Dr. Robert Lee is a  Professor of Pharmaceutics and Pharmaceutical Chemistry at The Ohio State  University College of Pharmacy. He graduated from Peking University in 1989 and  received his Ph.D. in Biological Sciences from Purdue University in 1994. He  received postdoctoral training at the University of Pittsburgh School of  Medicine and worked in the industry for 2.5 years before joining Ohio State as a  faculty member in 1997.  His research is in the area of developing drug delivery  systems for cancer and other human diseases. He has published over 200 original  research articles. He regularly serves on NIH grant review panels. He was a  co-PI of an NSF Nanoscale Science and Engineering Center (NSEC) and is a member  of the OSU Comprehensive Cancer Center and adjunct faculty of the Department of  Biomedical Engineering.